Research

Research Interests

Posted in Research on 二月 6th, 2013 by Delta – 评论关闭

Catalytic Asymmetric Dearomatization (CADA) Reaction

Aromatic compounds are widely distributed in nature and serve as abundant chemical feedstock in both academia and industry. Apart from plenty of efficient methods to introduce substituents onto numerous aromatic rings, dearomatization reactions are also important transformations of aromatic compounds as they provide straightforward accesses to polycyclic scaffolds with quaternary carbon centers. A major interest of You Group focuses on the development of highly efficient catalytic asymmetric dearomatization reactions. Various organocatalysts and transition metal complexes are found potent catalytic systems to realize the asymmetric dearomatization of indoles, pyrrole, phenols, etc. to furnish enantioenriched spiro or bridged polycyclic compounds, some of which are key structures of biologically active molecules.

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Selective Direct C–H Bond Functionalization

To pursuit the direct functionalization of inert C–H bond is of great importance in modern synthetic chemistry since it could avoid the “pre-activation” and thus met the criteria of atom economy. The great challenge accompanied is how to distinguish the reactivity between numerous C–H bonds in a single molecule and achieve the versatile functionalization in a highly efficient way. You Group utilizes small organic molecules and well-defined transition metal complexes to catalyze the selective direct transformation of non-activated C–H bonds to the corresponding C–C and C–Y bonds, with a special emphasis on its enantioselective variants.

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